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Richard Rosch
Interests and Bio

I am a clinically trained neuroscientist, interested in the dynamics of large-scale neuronal networks, particularly in the context of childhood epilepsies and other neurological conditions. In my work I combine a variety of computational methods to understand the link between dysfunction at the level of individual neurons and whole-brain abnormal dynamics of the sort seen in patients with epileptic seizures. 

After have completed my undergraduate neuroscience and medical degrees at the University of Oxford, I started postgraduate clinical training at King's College Hospital, London. At King's I was introduced to the fascinating new insights genomic medicine could offer for the care of paediatric epilepsy patients. I followed this interest by undertaking a PhD at in Theoretical Neurobiology, learning computational tools to interrogate the mechanisms underlying the dynamic brain abnormalities seen on functional brain imaging and EEG.

This year I am starting a new position as a Sir Henry Wellcome Postdoctoral Fellow at King's College London, where I will explore how we can use computational modelling to translate between insights from animal models and patient recordings. For this I will focus on two key genetic epilepsies and link clinical findings from patients with detailed light sheet microscopy recordings from corresponding zebrafish models of the disorders. 

 

Research Principles

Open Science
Scientific research relies on public support and thought exchange. To increase the reach and value of my research, I try and make as much of it openly available as possible.

Clinical Translation
With a background in clinical child neurology, I'm particularly interested in identifying new paths towards linking clinical practice and neuroscience research.

Public Engagement
Many stakeholders in our research are not scientists themselves. I'm always keen to explore new initiatives to engage wider audience in scientific research and its implications. 

 

 
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Richard Rosch
Curriculum Vitae

 

ACADEMIC POSITIONS

Sir Henry Wellcome Postdoctoral Fellow
King's College London (UK)
University of Pennsylvania (USA)
Stanford University (USA)
2018 - 2022

Oakgrove Foundation Postdoctoral Fellow
University College London (UK)
2018

Wellcome Trust Clinical PhD Fellow
University College London (UK)
2014 - 2017


CLINICAL EXPERIENCE

Honorary Fellow in Paediatric Epilepsy
Great Ormond St Hospital (UK)
2014 - 2018

Epilepsy and Neurophysiology Course
Cleveland Clinic (USA)
2016

Academic Foundation Training
King's College Hospital (UK)
2012 - 2014

Subintern, Paediatric Neurology
Johns Hopkins Hospital (USA)
2012

 
 

QUALIFICATIONS

MRCPCH (Membership of the Royal College of Paediatrics and Child Health)
Royal College of Paediatrics and Child Health, London (UK)
2017

ECFMG Certification
Educational Commission for Foreign Medical Graduates, (USA)
2017

BMBCh (Bachelor of Medicine and Bachelor of Surgery) - Merit
Magdalen College, University of Oxford (UK) 
2012

MA Interdisciplinary Arts, Social Sculpture Distinction
Oxford Brookes University
2011

BA (Hons) Medical Sciences First Class Honours
Magdalen College, University of Oxford
2006


PREPRINTS
 

[4] Rosch RE, Wright S, Cooray G, Papadopoulou M, Goyal S, Lim M, Vincent A, Upton LA, Baldeweg T, Friston KJ (2017) NMDA-receptor antibodies alter cortical microcircuit dynamics bioRxiv, doi.org/10.1101/160309

[3] Rosch RE*, Hunter P, Baldeweg T, Friston KJ, Meyer MP (2017) Imaging and dynamic causal modelling reveal brain-wide changes in effective connectivity and synaptic dynamics during epileptic seizures. bioRxiv, doi.org/10.1101/160259. *equal contribution

[2] Rosch RE, Auksztulewicz R, Leung PD, Friston KJ, Baldeweg T (2017) NMDA receptor blockade causes selective prefrontal disinhibition in a roving auditory oddball paradigm. bioRxiv, doi.org/10.1101/133371

[1] Cooray GK, Rosch R, Baldeweg T, Lemieux L, Friston KJ, Sengupta B (2017) Bayesian Belief Updating of Spatiotemporal Seizure Dynamics. arXiv:1705.07278

PUBLICATIONS

[18] Pal DK, Oates S, Tang S, Rosch R, Lear R, Hughes E, Williams R, Moller R, Larsen L, Hao Q, Dahl H (2018) Incorporating epilepsy genetics into clinical practice: a 360 degree evaluation. npj Genomic Medicine, in press. 

[17] Rosch RE, Baldeweg T, Moeller F, Baier G (2018) Network dynamics in the healthy and epileptic developing brain. Network Neuroscience, 2(1), 41-59, doi.org/10.1162/NETN_a_00026

[16] Rosch RE, Cowell PE, Gurd JM (2018) Cerebellar asymmetry and cortical connectivity in monozygotic twins with discordant handedness. Cerebellum. 17, 191-203, doi.org/10.1007/s12311-017-0889-y

[15] Devakumar D, Bamford A, Ferreira MU, Broad J, Rosch RE, Groce N, Breuer J, Bardaso MA, Copp AJ, Alexandre P, Rodrigues LC, Abubakar I (2018) Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management. Lancet Infect Dis, 18(1): e1-e13, doi.org/10.1016/S1473-3099(17)30398-5

[14] Rosch RE, Heys M, Kuper H (2017) Child development and childhood disability: A global perspective. In Global Maternal and Child Health. Oxford University Press. Oxford, UK. 

[13] Omidvarnia A, Pedersen M, Rosch R, Friston K, Jackson G (2017) Hierarchical disruption in the Bayesian brain: Focal epilepsy and brain networks. NeuroImage Clin, 15, 682-8, doi.org/10.1016/j.nicl.2017.05.019 

[12] Friston KJ, Rosch R, Parr T, Price C, Bowman H (2017) Deep temporal models and active inference. Neuroscience and Biobehavioural Reviews, 77, 388-402, doi.org/10.1016/j.neubiorev.2017.04.009 

[11] Baier G, Rosch R, Taylor PN, Wang Y (2017) Design principles for a population-model of epileptic dynamics. In Complexity and Synergtics. Springer International Publishing. Cham, Switzerland. [£]

[10] Peters C*, Rosch RE*, Hughes E, Ruben PC (2016) Temperature-dependent changes in neuronal dynamics in a patient with an SCN1A mutation and hyperthermia induced seizures. Sci Rep, 6, 31879 . *equal contribution, doi.org/10.1038/srep31879

[9] Rosch RE, Farquhar M, Gringras P, Pal DK (2016) A case report of narcolepsy following yellow fever vaccination. Front Neurol 7, 130, doi.org/10.3389/fneur.2016.00130

[8] Rosch RE, Cooray G, Friston K (2016) Dynamic causal modelling of dynamic dysfunction in NMDA-Receptor Antibody Encephalitis. In: Computational Neurology and Psychiatry. Springer International Publishing. Cham, Switzerland, doi.org/10.1007/978-3-319-49959-8_6 [£]

[7] Papadopoulou M, Cooray G, Rosch RE, Moran R, Marinazzo D, Friston K (2016) Dynamic causal modelling of seizure activity in a rat model. NeuroImage, 146, 518-32, doi.org/10.1016/j.neuroimage.2016.08.062

[6] Addis L, Rosch RE, Valentin A, Makoff A, Robinson R, Everett K, Nashef L, Pal DK (2016) Analysis of rare copy number variation in absence epilepsies. Neurol Genet, 2, e56, doi.org/10.1212/NXG.0000000000000056

[5] Boyce R, Rosch R, Finlayson A, Handuleh D, Walhad SA, Whitwell S, Leather A (2015) The use of a bibliometric literature review to assess medical research capacity in post-conflict and developing countries: Somaliland 1991-2013 Tropical Medicine and International Health, 20, 1507-15, doi.org/10.1111/tmi.12590

[4] Rosch RE*, Bamford A*, Hacohen Y, Vincent A, Wraige E, Mewasingh L, Lim M (2014) Guillain Barré syndrome associated with Caspr2 antibodies: two paediatric cases. J Periph Nerv Sys, 19, 246-9. *equal contribution, doi.org/10.1111/jns.12089 [£]

[3] Rosch RE, Badcock N, Bishop D (2012) Lateralised visual attention is unrelated to language lateralisation, and not influenced by task difficulty - A functional transcranial Doppler study. Neuropsychologia, 50, 810-5, doi.org/10.1016/j.neuropsychologia.2012.01.015 

[2] Banissy MJ, Annett LE, Asiedu-Offei P, Rosch R, Gurd JM (2012) Left, right, hand ‘n space. In Handedness: Theories, Genetics and Psychology. Nova Science Publishers, Hauppauge, NY.

[1] Rosch RE, Ronan L, Cherkas L, Gurd J (2010) Cerebellar asymmetry in a pair of monozygotic handedness discordant twins. Journal of Anatomy 217, 38-47, doi.org/10.1111/j.1469-7580.2010.01244.x

PEER REVIEW
 

Journals

  • Biological Psychiatry
  • Cortex
  • Developmental Cognitive Neuroscience
  • Frontiers in Computational Neuroscience
  • NeuroImage: Clinical

Book Publishers

  • Springer Publishing
  • Routledge

Grants

  • King's Health Partners

SOCIETY MEMBERSHIP

  • British Paediatric Neurology Association (BPNA)
  • Society for Neuroscience (SfN)

FUNDING

  • Sir Henry Wellcome Postdoctoral Fellowship
    (Principal Applicant 209164/Z/17/Z £250,000)
  • Oakgrove Foundation Postdoctoral Fellowship (Principal Applicant £27,000)
  • UCL Knowledge Exchange Champions Award
    (Co-applicant, £10,000) 
  • Dravet.ca Research Award
    (Co-applicant, CA$20,000)
  • UCL - French Embassy Collaborative Workshop Grant
    (Co-applicant, £4,425) 
  • Wellcome Trust Clinical Research Fellowship
    (Principal Applicant 106556/Z/14/Z; 2014-17, £250,000)
  • Isaac Schapera Research Trust Award (2013, £900)

AWARDS

  • ICTALS2017 Travel Award (international, 2017, $1,000)
  • IWSP7 Travel Award (international, 2015, AUS$1500)
  • UCB Educational Grant (national, 2015, £350)
  • OIST Molecular Neuroanatomy Grant (international, 2014, Workshop Attendance)
  • ENS Neurologist in Training Grant (international, 2013, Conference Attendance)
  • RCPCH Foundation Prize (national, 2013, Conference Attendance)
  • Miss Ford Bursary, Anglo French Medical Society (international, 2012, £350) 
  • Guarantors of Brain Travel Grant (national, 2011, £800)
  • Oxford University Psychiatry Merit (2011)
  • Magdalen College Edward Chapman Research Prize (2011, £500)
  • Magdalen College Apgar Prize for Teaching Excellence (2010, £1000) 
  • Oxford University Association of Physicians Prize (2009, £250)
  • Oxford University Wronker Grant (2009, £125)
  • Magdalen College Undergraduate Research Grant (2008, £450)
  • Magdalen College Sherrington-Sinclair Prize (2008, £125)
  • Magdalen College Academic Exhibition (2007-09, £200)
  • German Academic Foundation Scholarship (2006-12)

INVITED TALKS
 

Rosch RE (2018) Seizure dynamics in mice and men. Network Inference and Random Dynamics. The ReconNeCT Project, Imperial College London. 

Rosch RE (2018) Modelling epileptogenic networks from stereotactic EEG recordings. Brain Networks and Neurological Disorders: From Theory to Clinic, University of Exeter. 

Rosch RE (2017) Accumulating Evidence in Dynamic Causal Modelling. Richardson Lab Seminar Series. King’s College London, UK.

Rosch RE (2017) Network and microcircuit dynamics in EEG. Multiscale models of intracranial EEG recordings. Newcastle University, UK.

Rosch RE (2015) Anti-NMDAR causes changes synaptic dynamics in paediatric patients. Building Models; Understanding Brain. Lincoln University, UK.

Rosch RE (2012) Taking Sides. A developmental perspective on laterality. The Laboratory for the Brain Basis of Individual Differences, Harvard University, Boston US.

Rosch RE (2011) Which side is which? Laterality and Language. Oxford University Phonetics Laboratory Speech Lunch, Oxford, UK
 


TEACHING

Teaching for clinicians

  • Research education lead, King’s Somaliland Partnership (2014-now)
  • General medicine lead, King’s Somaliland Partnership (2012-2015)


Teaching for graduate students

  • Guest lecturer, MSc Advanced Paediatric Neuropsychology, University College London (2015-now)
  • Research supervisor, MSc in Clinical Neuroscience, University College London (2015-now)
  • Bedside tutor, MSc in Clinical Neurology, University College London (2015-2017)
  • Guest lecturer, MSc in Clinical Neuroscience, King’s College London (2013)

Teaching for undergraduate students

  • Examiner, iBSc in Global Maternal and Child Health, University College London (2018) 
  • Research Supervisor, iBSc in Global Health, King’s College London (2015-2017)
  • Summer Academy, mixed undergraduate students, German Academic foundation (2015)
  • Associate tutor in Neurology, clinical medicine students, King’s College London (2012-2014)
  • Neuroscience tutor, pre-clinical students, University of Oxford (2009-2012)

Teaching for highschool students

  • Summer academy, 11-14 year old students, JuniorAkademie Germany (2009)