Interests and Bio
I am a clinically trained neuroscientist, interested in the dynamics of large-scale neuronal networks, particularly in the context of childhood epilepsies and other neurological conditions. In my work I combine a variety of computational methods to understand the link between dysfunction at the level of individual neurons and whole-brain abnormal dynamics of the sort seen in patients with epileptic seizures.
After have completed my undergraduate neuroscience and medical degrees at the University of Oxford, I started postgraduate clinical training at King's College Hospital, London. At King's I was introduced to the fascinating new insights genomic medicine could offer for the care of paediatric epilepsy patients. I followed this interest by undertaking a PhD at in Theoretical Neurobiology, learning computational tools to interrogate the mechanisms underlying the dynamic brain abnormalities seen on functional brain imaging and EEG.
This year I am starting a new position as a Sir Henry Wellcome Postdoctoral Fellow at King's College London, where I will explore how we can use computational modelling to translate between insights from animal models and patient recordings. For this I will focus on two key genetic epilepsies and link clinical findings from patients with detailed light sheet microscopy recordings from corresponding zebrafish models of the disorders.
Scientific research relies on public support and thought exchange. To increase the reach and value of my research, I try and make as much of it openly available as possible.
With a background in clinical child neurology, I'm particularly interested in identifying new paths towards linking clinical practice and neuroscience research.
Many stakeholders in our research are not scientists themselves. I'm always keen to explore new initiatives to engage wider audience in scientific research and its implications.
Sir Henry Wellcome Postdoctoral Fellow
King's College London (UK)
University of Pennsylvania (USA)
2018 - 2022
Oakgrove Foundation Postdoctoral Fellow
University College London (UK)
Wellcome Trust Clinical PhD Fellow
University College London (UK)
2014 - 2017
Honorary Fellow in Paediatric Neurology
Great Ormond St Hospital (UK)
2014 - 2019
Epilepsy and Neurophysiology Course
Cleveland Clinic (USA)
Academic Foundation Training
King's College Hospital (UK)
2012 - 2014
Subintern, Paediatric Neurology
Johns Hopkins Hospital (USA)
PhD Theoretical Neurobiology (Doctor of Philosophy)
University College London, London (UK)
MRCPCH (Membership of the Royal College of Paediatrics and Child Health)
Royal College of Paediatrics and Child Health, London (UK)
MA Interdisciplinary Arts, Social Sculpture – Distinction
Oxford Brookes University
Educational Commission for Foreign Medical Graduates, (USA)
BA (Hons) Medical Sciences – First Class Honours
Magdalen College, University of Oxford
BMBCh (Bachelor of Medicine and Bachelor of Surgery) - Merit
Magdalen College, University of Oxford (UK)
 Cooray GK, Rosch R, Baldeweg T, Lemieux L, Friston KJ, Sengupta B (2017) Bayesian Belief Updating of Spatiotemporal Seizure Dynamics. arXiv:1705.07278
 Traub R, Moeller F, Rosch RE, Baldeweg T, Whittington MA, Hall SP (2019) Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms. Rev Neurosci, in press.
 Hamburg S*, Rosch RE*, Startin CM, Friston KJ, Strydom A (2019) Dynamic causal modelling of the relationship between cognition adn theta-alpha oscillations in adults with Down Syndrome. Cerebr Cortex, bhz043. doi.org/10.1093/cercor/bhz043 *equal contribution
 Rosch RE, Wright S, Cooray G, Papadopoulou M, Goyal S, Lim M, Vincent A, Upton LA, Baldeweg T, Friston KJ (2017) NMDA-receptor antibodies alter cortical microcircuit dynamics. PNAS, 115(42), doi.org/10.1073/pnas.1804846115
 Rosch RE*, Hunter P*, Baldeweg T, Friston KJ, Meyer MP (2017) Imaging and dynamic causal modelling reveal brain-wide changes in effective connectivity and synaptic dynamics during epileptic seizures. PLoS Comp Biol, doi.org/10.1371/journal.pcbi.1006375 *equal contribution
 Rosch RE, Auksztulewicz R, Leung PD, Friston KJ, Baldeweg T (2017) NMDA receptor blockade causes selective prefrontal disinhibition in a roving auditory oddball paradigm. doi.org/10.1016/j.bpsc.2018.07.003
 Pal DK, Oates S, Tang S, Rosch R, Lear R, Hughes E, Williams R, Moller R, Larsen L, Hao Q, Dahl H (2018) Incorporating epilepsy genetics into clinical practice: a 360 degree evaluation. npj Genomic Medicine, in press.
 Rosch RE, Baldeweg T, Moeller F, Baier G (2018) Network dynamics in the healthy and epileptic developing brain. Network Neuroscience, 2(1), 41-59, doi.org/10.1162/NETN_a_00026
 Rosch RE, Cowell PE, Gurd JM (2018) Cerebellar asymmetry and cortical connectivity in monozygotic twins with discordant handedness. Cerebellum. 17, 191-203, doi.org/10.1007/s12311-017-0889-y
 Devakumar D, Bamford A, Ferreira MU, Broad J, Rosch RE, Groce N, Breuer J, Bardaso MA, Copp AJ, Alexandre P, Rodrigues LC, Abubakar I (2018) Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management. Lancet Infect Dis, 18(1): e1-e13, doi.org/10.1016/S1473-3099(17)30398-5
 Rosch RE, Heys M, Kuper H (2017) Child development and childhood disability: A global perspective. In Global Maternal and Child Health. Oxford University Press. Oxford, UK.
 Omidvarnia A, Pedersen M, Rosch R, Friston K, Jackson G (2017) Hierarchical disruption in the Bayesian brain: Focal epilepsy and brain networks. NeuroImage Clin, 15, 682-8, doi.org/10.1016/j.nicl.2017.05.019
 Friston KJ, Rosch R, Parr T, Price C, Bowman H (2017) Deep temporal models and active inference. Neuroscience and Biobehavioural Reviews, 77, 388-402, doi.org/10.1016/j.neubiorev.2017.04.009
 Baier G, Rosch R, Taylor PN, Wang Y (2017) Design principles for a population-model of epileptic dynamics. In Complexity and Synergtics. Springer International Publishing. Cham, Switzerland. [£]
 Peters C*, Rosch RE*, Hughes E, Ruben PC (2016) Temperature-dependent changes in neuronal dynamics in a patient with an SCN1A mutation and hyperthermia induced seizures. Sci Rep, 6, 31879 . *equal contribution, doi.org/10.1038/srep31879
 Rosch RE, Farquhar M, Gringras P, Pal DK (2016) A case report of narcolepsy following yellow fever vaccination. Front Neurol 7, 130, doi.org/10.3389/fneur.2016.00130
 Rosch RE, Cooray G, Friston K (2016) Dynamic causal modelling of dynamic dysfunction in NMDA-Receptor Antibody Encephalitis. In: Computational Neurology and Psychiatry. Springer International Publishing. Cham, Switzerland, doi.org/10.1007/978-3-319-49959-8_6 [£]
 Papadopoulou M, Cooray G, Rosch RE, Moran R, Marinazzo D, Friston K (2016) Dynamic causal modelling of seizure activity in a rat model. NeuroImage, 146, 518-32, doi.org/10.1016/j.neuroimage.2016.08.062
 Addis L, Rosch RE, Valentin A, Makoff A, Robinson R, Everett K, Nashef L, Pal DK (2016) Analysis of rare copy number variation in absence epilepsies. Neurol Genet, 2, e56, doi.org/10.1212/NXG.0000000000000056
 Boyce R, Rosch R, Finlayson A, Handuleh D, Walhad SA, Whitwell S, Leather A (2015) The use of a bibliometric literature review to assess medical research capacity in post-conflict and developing countries: Somaliland 1991-2013 Tropical Medicine and International Health, 20, 1507-15, doi.org/10.1111/tmi.12590
 Rosch RE*, Bamford A*, Hacohen Y, Vincent A, Wraige E, Mewasingh L, Lim M (2014) Guillain Barré syndrome associated with Caspr2 antibodies: two paediatric cases. J Periph Nerv Sys, 19, 246-9. *equal contribution, doi.org/10.1111/jns.12089 [£]
 Rosch RE, Badcock N, Bishop D (2012) Lateralised visual attention is unrelated to language lateralisation, and not influenced by task difficulty - A functional transcranial Doppler study. Neuropsychologia, 50, 810-5, doi.org/10.1016/j.neuropsychologia.2012.01.015
 Banissy MJ, Annett LE, Asiedu-Offei P, Rosch R, Gurd JM (2012) Left, right, hand ‘n space. In Handedness: Theories, Genetics and Psychology. Nova Science Publishers, Hauppauge, NY.
 Rosch RE, Ronan L, Cherkas L, Gurd J (2010) Cerebellar asymmetry in a pair of monozygotic handedness discordant twins. Journal of Anatomy 217, 38-47, doi.org/10.1111/j.1469-7580.2010.01244.x
Developmental Cognitive Neuroscience
Frontiers in Computational Neuroscience
Journal of Neuroscience
Journal of Nonlinear Scien
King's Health Partners
British Paediatric Neurology Association (BPNA)
British Neuroscience Association (BNA)
Federation of European Neuroscience Societies (FENS)
Society for Neuroscience (SfN)
Fellow of the Royal Society of Arts (FRSA)
Member of the Institute of Physics
Sir Henry Wellcome Postdoctoral Fellowship
(2018, Principal Applicant 209164/Z/17/Z £250,000)
Oakgrove Foundation Postdoctoral Fellowship (2017, Principal Applicant £27,000)
UCL Knowledge Exchange Champions Award
(2016, Co-applicant, £10,000)
Dravet.ca Research Award
(2016, Co-applicant, CA$20,000)
UCL - French Embassy Collaborative Workshop Grant
(2016, Co-applicant, £4,425)
Wellcome Trust Clinical Research Fellowship
(2014, Principal Applicant 106556/Z/14/Z; 2014-17, £250,000)
Isaac Schapera Research Trust Award (2013, £900)
FENS Travel Award (international, 2019, €600)
GRC Travel Award (international, 2018, $1000)
ICTALS2017 Travel Award (international, 2017, $1,000)
IWSP7 Travel Award (international, 2015, AUS$1500)
UCB Educational Grant (national, 2015, £350)
OIST Molecular Neuroanatomy Grant (international, 2014, Workshop Attendance)
ENS Neurologist in Training Grant (international, 2013, Conference Attendance)
RCPCH Foundation Prize (national, 2013, Conference Attendance)
Miss Ford Bursary, Anglo French Medical Society (international, 2012, £350)
Guarantors of Brain Travel Grant (national, 2011, £800)
Oxford University Psychiatry Merit (2011)
Magdalen College Edward Chapman Research Prize (2011, £500)
Magdalen College Apgar Prize for Teaching Excellence (2010, £1000)
Oxford University Association of Physicians Prize (2009, £250)
Oxford University Wronker Grant (2009, £125)
Magdalen College Undergraduate Research Grant (2008, £450)
Magdalen College Sherrington-Sinclair Prize (2008, £125)
Magdalen College Academic Exhibition (2007-09, £200)
German Academic Foundation Scholarship (2006-12)
Epileptic networks in zebrafish. (2019) New insights from a novel animal model. Epilepsy Research UK Expert Workshop, Oxford, UK
NMDA receptor antibodies alter cortical microcircuit dynamics (2019). British Paediatric Neurology Association Annual Meeting, Liverpool, UK.
From molecules to networks. Linking molecular mechanisms to whole-brain phenotypes (2018) Poduri Lab Meeting. Boston Children’s Hospital, USA
Multiscale modelling of abnormal brain dynamics (2018) Brain Centre Seminars. Aston University, UK
Seizure dynamics in mice and men (2018) Network Inference and Random Dynamics. The ReconNeCT Project, Imperial College London.
Modelling epileptogenic networks from stereotactic EEG recordings (2018) Brain Networks and Neurological Disorders: From Theory to Clinic, University of Exeter.
Accumulating Evidence in Dynamic Causal Modelling (2017) Richardson Lab Seminar Series. King’s College London, UK.
Network and microcircuit dynamics in EEG (2017) Multiscale models of intracranial EEG recordings. Newcastle University, UK.
Anti-NMDAR causes changes synaptic dynamics in paediatric patients (2015) Building Models; Understanding Brain. Lincoln University, UK.
Taking Sides (2012) A developmental perspective on laterality. The Laboratory for the Brain Basis of Individual Differences, Harvard University, Boston US.
Which side is which? (2011) Laterality and Language. Oxford University Phonetics Laboratory Speech Lunch, Oxford, UK
Teaching for clinicians
Research education lead, King’s Somaliland Partnership (2014-now)
General medicine lead, King’s Somaliland Partnership (2012-2015)
Teaching for graduate students
Guest lecturer, MSc Advanced Paediatric Neuropsychology, University College London (2015-now)
Research supervisor, MSc in Clinical Neuroscience, University College London (2015-2018)
Bedside tutor, MSc in Clinical Neurology, University College London (2015-2017)
Guest lecturer, MSc in Clinical Neuroscience, King’s College London (2013)
Teaching for undergraduate students
Examiner, iBSc in Global Maternal and Child Health, University College London (2018)
Research Supervisor, iBSc in Global Health, King’s College London (2015-2017)
Summer Academy, mixed undergraduate students, German Academic foundation (2015)
Associate tutor in Neurology, clinical medicine students, King’s College London (2012-2014)
Neuroscience tutor, pre-clinical students, University of Oxford (2009-2012)
Teaching for highschool students
Summer academy, 11-14 year old students, JuniorAkademie Germany (2009)